Chapter Updated: Lung Cancer

• March 2nd, 2012

Chapter 58 has been updated by authors Barry D. Nelkin, Ph.D. and Stephen B. Baylin, M.D.  Click Here to read the abstract.

DOI Reference Number : http://dx.doi.org/10.1036/ommbid.74

IDH1 mutation in gliomas

• April 7th, 2010

Certain gliomas have somatic mutation in cytosolic isocitrate dehydrogenase 1. Dang et al. have shown that these mutations confer the enzyme the new ability to transform alpha-ketoglutarate in 2-hydroxyglutarate. This metabolite might be oncogenic, although this is not proven yet.

Dang L, White DW, Gross S, et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature 2009;462:739-744

Philippe Campeau